Pyrimidine series intermediates
Pyrimidine, also known as 1,3-diazepine, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by replacing 2 carbons in the meta-position of benzene with 2 nitrogen atoms, and is a diazine. Like pyridine, pyrimidine retains its aromaticity.
Introduction
Name: Pyrimidine
Molecular formula: C4H4N2
Molar mass: 80.09 g/mol
Density: 1.016 g/ml
Melting point: 20 - 22 °C
Boiling point: 123 - 124 °C
CAS Number: 289-95-2
EINECS Number: 206-026-0
SMILES: C1=NC=NC=C1
Application
(1) Anticancer drugs. In the selection of anticancer substances, it is crucial that there are significant differences between tumor tissues and normal tissues, that is, they have a certain ability to recognize target cells. Porphyrin compounds have special affinity for cancer cells due to their unique structures, and they can selectively stay in cancer tissues. The research of it as a localizing agent and a drug for diagnosis and treatment of cancer has already aroused great interest of chemists, medical scientists and biologists. 5-Fluorouracil is a widely used anti-metabolite and anti-tumor drug in clinic. It has inhibitory effect on various tumors. It has good clinical effect in the treatment of colorectal cancer, gastric cancer, breast cancer and other cancers. Polyesters, polyester hydrocarbons, polyester amides, deoxyribonucleic acid, furans, 5-fluorouracil derivatives linked to nitroxide radicals all have antitumor effects.
(2) Anti-AIDS drugs. Viral diseases have become one of the most harmful diseases to human beings, especially the spread of AIDS, which has aroused widespread concern. There are many kinds of anti-AIDS drugs that have been approved by the US Food Administration (FDA), many of which are nucleoside compounds. In order to reduce the toxicity of drugs and improve their efficacy, scientists have begun to turn their attention to the study of non-nucleoside compounds, and such compounds have become the focus of antiviral drug research.
Synthetic method
Pyrimidines and various substituted pyrimidines are synthesized in a variety of ways. For example, barbituric acid (2,4,6-trihydroxypyrimidine) can be obtained by the condensation of urea and diethyl malonate under the action of sodium alkoxide. Barbituric acid and phosphorus oxychloride are heated together to obtain 2,4,6-trichloropyrimidine, which reacts with sodium methoxide to obtain trimethoxypyrimidine. Chloropyrimidines react with ammonia or primary and secondary amines to generate the corresponding aminopyrimidines. The derivatives of pyrimidine, cytosine, uracil and thymine, are the constituent parts of nucleic acid and deoxynucleic acid, and the pyrimidine part in the vitamin B1 molecule is a 4-amino-2-methyl-5-pyrimidine methyl group. Many oral long-acting sulfa drugs are derivatives of pyrimidine and its isomers.
The 2,4-dichloropyrimidine is prepared by reduction reaction in the presence of palladium, magnesium oxide and activated carbon.
Pyrimidine Series Intermediates,2-Chloro-5-Methylpyrimidine,5-Bromo-2-chloropyrimidine,2 4-Dichloro-5-Methylpyrimidine Fuxin Custchem Fine Chemical Co., Ltd. , https://www.custchemvip.com
 Copper Cable Granulator
Production Capacity: 200-1000kg/h
Utility Model Patent: ZL 2010 2 0582466.4
The cable recycling machine is one of our products that are developed on our own. It is usually used to produce copper and recycle plastic granules. The separator is independently developed by ourselves and has rational structure, stable operation performance, and so on.
The separator of the cable recycling equipment is suitable for processing all kinds of cables. It can separate copper from plastic effectively by crushing, vibrating screening separation and vibration separation so as to achieve comprehensive utilization. It features good cost effectiveness, dust-free producing progress and second pollution-free property.
Besides, the cable recycling line can facilitate the installation, test running and delivery. You can just put it into use immediately when you receive it. Moreover, during the whole production process, the cable recycling facility only needs to be fed once because the volume for material is quite big. Custom products are available according to customers' requirements.
Model: 1000kg
Output kg/h1000
Machinery:
-Single sharft shredder WT4080
-Center Dust Removing System
-Boil Separator
-Static Separator
-Center Dust Removing System
Application:Â
This type machine is specially used for crushing and processing auto electrical wires and communication cables and other wires the diameter of the wires is less than 20mm and the wires are not suited to use wire stripping machine.Â
It works by many machine combination, crusher, vibration screen, dedust., conveyor, exhaust fan, motor etc. Copper can be completely separated by the metal screening. The separated copper is bright and smooth and has a purity up to 99%. It is an indispensable environment friendly machine control system in recycling waste cables and other relevant industries.Â
The copper which separated by the machine can remain the quality of the original copper, and the plastic can be recycled.Â
Feature:Â
(1) the automation degree of the whole line is high, it is easy to operate.Â
(2) during the process of sorting, PE, PVC and copper are recycled with 99%.Â
(3) the seperating copper has a purity up to 99%Â
(4)No pollutionÂ
(5) Energy savingÂ
(6) It is semi-permanent machine, only need to change the consumptive or wearing accessaries
 Copper Cable Granulator
Production Capacity: 200-1000kg/h
Utility Model Patent: ZL 2010 2 0582466.4
The cable recycling machine is one of our products that are developed on our own. It is usually used to produce copper and recycle plastic granules. The separator is independently developed by ourselves and has rational structure, stable operation performance, and so on.
The separator of the cable recycling equipment is suitable for processing all kinds of cables. It can separate copper from plastic effectively by crushing, vibrating screening separation and vibration separation so as to achieve comprehensive utilization. It features good cost effectiveness, dust-free producing progress and second pollution-free property.
Besides, the cable recycling line can facilitate the installation, test running and delivery. You can just put it into use immediately when you receive it. Moreover, during the whole production process, the cable recycling facility only needs to be fed once because the volume for material is quite big. Custom products are available according to customers' requirements.
Model: 1000kg
Output kg/h1000
Machinery:
-Single sharft shredder WT4080
-Center Dust Removing System
-Boil Separator
-Static Separator
-Center Dust Removing System
Application:Â
This type machine is specially used for crushing and processing auto electrical wires and communication cables and other wires the diameter of the wires is less than 20mm and the wires are not suited to use wire stripping machine.Â
It works by many machine combination, crusher, vibration screen, dedust., conveyor, exhaust fan, motor etc. Copper can be completely separated by the metal screening. The separated copper is bright and smooth and has a purity up to 99%. It is an indispensable environment friendly machine control system in recycling waste cables and other relevant industries.Â
The copper which separated by the machine can remain the quality of the original copper, and the plastic can be recycled.Â
Feature:Â
(1) the automation degree of the whole line is high, it is easy to operate.Â
(2) during the process of sorting, PE, PVC and copper are recycled with 99%.Â
(3) the seperating copper has a purity up to 99%Â
(4)No pollutionÂ
(5) Energy savingÂ
(6) It is semi-permanent machine, only need to change the consumptive or wearing accessaries
Copper Cable Granulator
Model NO.: Tairong
HS Code: 84778000
Model NO.: Tairong
HS Code: 84778000